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Medications that affect metabolism are prescribed only to treat diagnosed medical conditions such as hyperthyroidism, never for cosmetic weight management purposes

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Center equity: ensure diverse enrollment (race/ethnicity, age, socioeconomic status) so findings are generalizable

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doi: 10.3390/ijerph17082647

These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism